Sarah Brand

Sarah Brand

Is Ketamine Safe for Mental Health Treatment?

Exploring the Safety Profile of Ketamine Compared to Other Medications



Is ketamine safe for mental health treatment? Many individuals have questions and concerns about the safety of using ketamine as a therapeutic option. In this blog, we will delve into the safety record of ketamine, compare it to other commonly prescribed mental health medications, such as antidepressants and address common misconceptions about its use.


Ketamine’s Proven Safety Record:

Ketamine has a long history of safety in the medical field. Initially used as an anesthetic in surgeries, it quickly gained recognition for its safety profile. In fact, it is listed on the World Health Organization’s List of Essential Medicines. Ketamine was widely used as an anesthetic agent and analgesic for wounded soldiers and civilians in wars and conflicts. From the Vietnam War to Afghanistan, it was primarily in medical and field hospitals to provide pain relief and perform surgeries on injured individuals.


FDA Approval and Medical Use:

Ketamine received FDA approval for anesthesia in 1970, and it has been a staple in the arsenal of anesthesiologists and pain management specialists ever since. Its safety has been established through decades of use. Ketamine’s off-label use refers to the use other than FDA’s approved use as an anesthetic and analgesic.


Mental Health Benefits:

In recent years, ketamine’s mental health benefits have come to light. Numerous studies have reinforced its safety and efficacy in treating various mental health disorders, with some patients achieving complete remission after treatment. Our own patients have also reported dramatic change in mood and improvement in cognition and memory first time


Ketamine Dosage and Safety:

When it comes to safety, dosage is crucial. Anesthesia doses of ketamine are significantly higher than the subanesthetic doses used for mental health treatment. The lower doses used in mental health care are well-tolerated.


Comparative Safety:

Compared to standard mental health antidepressant medications like benzodiazepines and SSRIs, ketamine emerges as the safer option. Benzodiazepines carry a high risk of misuse and overdose, while SSRIs often lead to unwanted side effects such as: nausea, dry mouth, brain fog, weight changes, sexual dysfunction, fatigue, insomnia, agitation or anxiety, gastrointestinal issues, sweating, dizziness, tremors and withdrawal.


Rapid Relief:

One of ketamine’s advantages is its speed of action. Patients often experience symptom improvement within days, unlike traditional medications that may take weeks. Unlike antidepressant often takes weeks before noticing effect. This quick response can enhance patient compliance.


Neuroplasticity and Dissociation:

Experts believe ketamine promotes synaptic plasticity, which is the ability of neurons to strengthen their connections. Forming new neural pathways improves cognition and plays a crucial role in memory and emotional regulation. Ketamine’s dissociative effects may also contribute to its effectiveness by promoting neuroplasticity, the rewiring of the brain. These effects are seen as a potential benefit rather than a drawback.

Tolerability and Side Effects:

Ketamine, whether administered intravenously, intranasally or orally, is generally well-tolerated. Many patients even find their IV sessions to be pleasant, though some may experience dissociative effects, which are typically short-lived. Microdosing through oral tablets have even lower level of side effect.

Addressing Side Effects:

Nausea and vomiting are common side effects of ketamine, but they can be managed with medications. Transient blood pressure increases during IV infusion are also manageable and rarely occur with microdosing.

Misuse and Dependence

While any medication can be misused, the medical community has not observed high rates of dependence with ketamine. While recreational use for its hallucinogenic and dissociative effects has given it classified as a class III medication, but many experts believe this classification exaggerates its risk.

Comparing to Other Substances:

When compared to substances like psilocybin and marijuana (class I), ketamine’s safety profile remains more favorable. Misuse can lead to interstitial cystitis, a bladder disease, but it typically occurs with excessive recreational use, far beyond therapeutic doses.

Medical Supervision:

When used appropriately under medical supervision, ketamine has a low risk of dependence. Psychiatrists, anesthesiologists, and primary care providers who prescribe ketamine consistently attest to its safety in this context.


In conclusion, ketamine has a remarkable track record of safety spanning over 50 years in the medical community. Its use in mental health treatment has garnered significant support from scientific evidence. Ketamine is well-tolerated, fast-acting, and carries a low risk of dependence when administered by trained medical professionals. These factors contribute to its increasing popularity as a treatment option that can produce transformative results while ensuring patient safety.



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