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Sarah Brand

Sarah Brand

Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study

Glue, P., Neehoff, S., Sabadel, A., Broughton, L., Le Nedelec, M., Shadli, S., McNaughton, N., & Medlicott, N. J. (2019). Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study. Journal of Psychopharmacology, 34(3), 267–272.

Highlights:

  • The purpose of this study was to replicate our earlier report about ketamine’s anxiolytic activity, using a more robust study design.
  • This was a double-blind, psychoactive-controlled ascending dose study in 12 patients with treatment-resistant generalized anxiety and social anxiety disorders who were not currently depressed. Ascending doses of ketamine (0.25, 0.5, 1 mg/kg) were administered at weekly intervals, and midazolam 0.01 mg/kg, the control…
  • Improvements in anxiety ratings occurred within an hour of ketamine dosing and persisted for up to 1 week.
  • Midazolam had minor brief effects on anxiety ratings.
  • Ketamine was safe and well tolerated.

Results:

Improvements in anxiety ratings occurred within an hour of ketamine dosing and persisted for up to 1 week. A dose-response profile was noted for anxiolytic effects, dissociative side effects, and changes in blood pressure and heart rate after ketamine dosing. Midazolam had minor brief effects on anxiety ratings. Ketamine was safe and well tolerated. Ketamine pharmacokinetics were correlated with dissociation ratings. Serum BDNF concentrations declined over time and were similar for all treatments.

Conclusions:

Ketamine may be a potential therapeutic option for patients with treatment-resistant generalized anxiety and social anxiety disorders

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