Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
R.N. Moda-Sava, M.H. Murdock, P.K. Parekh, R.N. Fetcho, B.S. Huang, T.N. Huynh, J. Witztum, D.C. Shaver, D.L. Rosenthal, E.J. Alway, K. Lopoz, Y. Meng, L. Nellissen, L. Grosenick, T.A. Milner, K.Deisseroth, H. Bito, H. Kasai, C. Liston. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. 2019 Apr 12; Vol 364, Issue 6436. DOI: […]
(R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress. Ketamine demonstrates neuroplasticity. Neuroplasticity is hypothesized to be a key component to mental health recovery.
Zhang J, Qu Y, Chang L, Pu Y, Hashimoto K. (R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress. Int J Neuropsychopharmacol. 2019 Oct 1;22(10):675-679. doi: 10.1093/ijnp/pyz048. PMID: 31504547; PMCID: PMC6822137. Highlights: This study suggests that (R)-ketamine rapidly ameliorates the decreased spine […]
Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy.
Dore J, Turnipseed B, Dwyer S, Turnipseed A, Andries J, Ascani G, Monnette C, Huidekoper A, Strauss N, Wolfson P. Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy. J Psychoactive Drugs. 2019 Apr-Jun;51(2):189-198. doi: 10.1080/02791072.2019.1587556. Epub 2019 Mar 27. PMID: 30917760. Highlights: Our findings suggest […]
Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression.
Lara DR, Bisol LW, Munari LR. Antidepressant, mood stabilizing, and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression. Int J Neuropsychopharmacol. 2013 Oct;16(9):2111-7. doi: 10.1017/S1461145713000485. Epub 2013 May 20. PMID: 23683309. Highlights: According to patients’ reports, VLDS [very low dose sublingual] ketamine produced rapid, clear, and sustained effects, improving […]
Review of the science and meta-analysis to study the effectiveness of a single dose of ketamine therapy on suicidal ideation.
Wilkinson ST, Ballard ED, Bloch MH, Mathew SJ, Murrough JW, Feder A, Sos P, Wang G, Zarate CA Jr, Sanacora G. The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. Am J Psychiatry. 2018 Feb 1;175(2):150-158. doi: 10.1176/appi.ajp.2017.17040472. Epub 2017 Oct 3. PMID: 28969441; […]
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.
Anand, A et al. (2023). Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. N Engl J Med 2023;388:2315-25. DOI: 10.1056/NEJMoa2302399 Highlights: A total of 55.4% of the patients in the ketamine group and 41.2% of those in the ECT group had a response. Patients with treatment-resistant major depression without psychosis were recruited and assigned in […]
Ketamine triggers a switch in excitatory neuronal activity across neocortex.
Cichon, J., Wasilczuk, A.Z., Looger, L.L. et al. Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nat Neurosci (2022). Highlights: Ketamine reorganizes neuronal activity and switches on active circuits. In mice, this study demonstrates that ketamine causes spontaneously active neurons to become deactivated and reactivates prior spontaneously deactivated neurons. This switch occurs in […]
Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active-duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial.
Highlights: The standard ketamine dose-treated depression significantly more than placebo. Ketamine produced dose-related dissociative and psychotomimetic effects, which returned to baseline within 2 h and were less pronounced with repeated administration. Involved 158 veterans and service members with treatment-resistant PTSD that failed prior antidepressant treatments in the past. Veterans were divided into a placebo group, and […]
Ketamine normalizes subgenual cingulate cortex hyper-activity in depression.
Morris, L. S., Costi, S., Tan, A., Stern, E. R., Charney, D. S., & Murrough, J. W. (2020). Ketamine normalizes subgenual cingulate cortex hyper-activity in depression. Neuropsychopharmacology, 45(6), 975–981. Highlights: There was a significant improvement in MDD symptoms following a single-dose intravenous ketamine. Following a 40-minute infusion of ketamine at a dose of 0.5mg/kg, patients […]
Low-dose ketamine infusion in treatment-resistant double depression: Revisiting the adjunctive ketamine study of Taiwanese patients with treatment-resistant depression.
Chen, M. H., Wu, H. J., Li, C. T., Lin, W. C., Tsai, S. J., Hong, C. J., Tu, P. C., Bai, Y. M., Mao, W. C., & Su, T. P. (2021). Low-dose ketamine infusion in treatment-resistant double depression: Revisiting the adjunctive ketamine study of Taiwanese patients with treatment-resistant depression. Human Psychopharmacology: Clinical and Experimental, […]
