Review of the science and meta-analysis to study the effectiveness of a single dose of ketamine therapy on suicidal ideation.
Wilkinson ST, Ballard ED, Bloch MH, Mathew SJ, Murrough JW, Feder A, Sos P, Wang G, Zarate CA Jr, Sanacora G. The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. Am J Psychiatry. 2018 Feb 1;175(2):150-158. doi: 10.1176/appi.ajp.2017.17040472. Epub 2017 Oct 3. PMID: 28969441; […]
Productivity and Performance: Nutrition Hacks for Busy Professionals
Busy professionals are well aware of problems like chronic lack of concentration, declining energy levels, and high-stress levels. Furthermore, individuals involved in cognitive tasks are at a higher risk of experiencing burnout – physical, emotional or mental exhaustion, accompanied by decreased motivation, lowered performance and negative attitudes towards oneself and others. There could be many […]
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.
Anand, A et al. (2023). Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. N Engl J Med 2023;388:2315-25. DOI: 10.1056/NEJMoa2302399 Highlights: A total of 55.4% of the patients in the ketamine group and 41.2% of those in the ECT group had a response. Patients with treatment-resistant major depression without psychosis were recruited and assigned in […]
Ketamine triggers a switch in excitatory neuronal activity across neocortex.
Cichon, J., Wasilczuk, A.Z., Looger, L.L. et al. Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nat Neurosci (2022). Highlights: Ketamine reorganizes neuronal activity and switches on active circuits. In mice, this study demonstrates that ketamine causes spontaneously active neurons to become deactivated and reactivates prior spontaneously deactivated neurons. This switch occurs in […]
Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active-duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial.
Highlights: The standard ketamine dose-treated depression significantly more than placebo. Ketamine produced dose-related dissociative and psychotomimetic effects, which returned to baseline within 2 h and were less pronounced with repeated administration. Involved 158 veterans and service members with treatment-resistant PTSD that failed prior antidepressant treatments in the past. Veterans were divided into a placebo group, and […]
Ketamine normalizes subgenual cingulate cortex hyper-activity in depression.
Morris, L. S., Costi, S., Tan, A., Stern, E. R., Charney, D. S., & Murrough, J. W. (2020). Ketamine normalizes subgenual cingulate cortex hyper-activity in depression. Neuropsychopharmacology, 45(6), 975–981. Highlights: There was a significant improvement in MDD symptoms following a single-dose intravenous ketamine. Following a 40-minute infusion of ketamine at a dose of 0.5mg/kg, patients […]
Low-dose ketamine infusion in treatment-resistant double depression: Revisiting the adjunctive ketamine study of Taiwanese patients with treatment-resistant depression.
Chen, M. H., Wu, H. J., Li, C. T., Lin, W. C., Tsai, S. J., Hong, C. J., Tu, P. C., Bai, Y. M., Mao, W. C., & Su, T. P. (2021). Low-dose ketamine infusion in treatment-resistant double depression: Revisiting the adjunctive ketamine study of Taiwanese patients with treatment-resistant depression. Human Psychopharmacology: Clinical and Experimental, […]
Treatment resistant depression at a glance with traditional, first line antidepressant treatments, as well as a review of the evidence behind esketamine, psilocybin and pramipexole.
Kverno KS, Mangano E. Treatment-Resistant Depression: Approaches to Treatment. J Psychosoc Nurs Ment Health Serv. 2021 Sep;59(9):7-11. doi: 10.3928/02793695-20210816-01. Epub 2021 Sep 1. PMID: 34459676. Highlights: Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant […]
Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: Preliminary evidence.
Norbury, A., Rutter, S. B., Collins, A. B., Costi, S., Jha, M. K., Horn, S. R., Kautz, M., Corniquel, M., Collins, K. A., Glasgow, A. M., Brallier, J., Shin, L. M., Charney, D. S., Murrough, J. W., & Feder, A. (2021). Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: Preliminary evidence. […]
Ketamine and the Future of Rapid-Acting Antidepressants.
Lace M. Riggs and Todd D. Gould. Ketamine and the Future of Rapid-Acting Antidepressants. Annual Review of Clinical Psychology 2021 17:1, 207-231 Highlights: The therapeutic onset of traditional antidepressants is delayed by several weeks and many depressed patients fail to respond to treatment altogether. In contrast, subanesthetic ketamine can rapidly alleviate symptoms of depression […]
