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Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial.

Abdallah, C.G., Roache, J.D., Gueorguieva, R. et al. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacol. 47, 1574–1581 (2022). Highlights: The standard ketamine dose treated depression significantly more than placebo. Ketamine produced dose-related dissociative and psychotomimetic effects, which […]

Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy.

Dore J, Turnipseed B, Dwyer S, Turnipseed A, Andries J, Ascani G, Monnette C, Huidekoper A, Strauss N, Wolfson P. Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy. J Psychoactive Drugs. 2019 Apr-Jun;51(2):189-198. doi: 10.1080/02791072.2019.1587556. Epub 2019 Mar 27. PMID: 30917760. Highlights: Our findings suggest […]

Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active-duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial.

ketamine vs antidepressant

Highlights: The standard ketamine dose-treated depression significantly more than placebo. Ketamine produced dose-related dissociative and psychotomimetic effects, which returned to baseline within 2 h and were less pronounced with repeated administration. Involved 158 veterans and service members with treatment-resistant PTSD that failed prior antidepressant treatments in the past. Veterans were divided into a placebo group, and […]

Ketamine as treatment for post-traumatic stress disorder: A Review.

Liriano, F., Hatten, C., & Schwartz, T. L. (2019). Ketamine as treatment for post-traumatic stress disorder: A Review. Drugs in Context, 8, 1–7. Highlights: PTSD continues to be a problematic psychiatric condition that can be difficult to treat. SSRIs are the first-line treatment, and they are the only pharmaceutical class approved – their use may […]

Improvement in suicidal ideation after repeated ketamine infusions.

Albott, C. S., Lim, K. O., Forbes, M. K., Thuras, P., Wels, J., Tye, S., & Shiroma, P. (2019). 3525 Improvement in suicidal ideation after repeated ketamine infusions: Journal of Clinical and Translational Science, 3(s1), 46–46.   Highlights: This study showed significant improvement in suicidal ideation within 24 hours of the first ketamine infusion therapy […]

Efficacy, safety, and durability of repeated ketamine infusions for comorbid posttraumatic stress disorder and treatment-resistant depression.

Albott, C. S., Lim, K. O., Forbes, M. K., Erbes, C., Tye, S. J., Grabowski, J. G., Thuras, P., Batres-y-Carr, T.M., Wels, J., & Shiroma, P. R. (2018). Efficacy, safety, and durability of repeated ketamine infusions for comorbid posttraumatic stress disorder and treatment-resistant depression. The Journal of Clinical Psychiatry, 79(3). Highlights: Ketamine produced rapid and […]

Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder.

Feder, A., Parides, M. K., Murrough, J. W., Perez, A. M., Morgan, J. E., Saxena, S., Kirkwood, K., aan het Rot, M., Lapidus, K. A., Wan, L.-B., Iosifescu, D., & Charney, D. S. (2014). Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder. JAMA Psychiatry, 71(6), 681–688 Highlights: Objective: To test the efficacy […]

Transient resolution of treatment-resistant posttraumatic stress disorder following ketamine infusion.

D’Andrea, D., & Sewesll, R. A. (2013). Transient resolution of treatment-resistant posttraumatic stress disorder following ketamine infusion. Biological Psychiatry, 74(9), e13–e14.  Highlights: An N-methyl-D-aspartate (NMDA) receptor antagonist with μ-opioid receptor effects, ketamine causes depression remission in most clinical trials attracting interest as a rapid-acting antidepressant We describe a case in which ketamine was given for treatment-resistant […]