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Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy.

Dore J, Turnipseed B, Dwyer S, Turnipseed A, Andries J, Ascani G, Monnette C, Huidekoper A, Strauss N, Wolfson P. Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy. J Psychoactive Drugs. 2019 Apr-Jun;51(2):189-198. doi: 10.1080/02791072.2019.1587556. Epub 2019 Mar 27. PMID: 30917760. Highlights: Our findings suggest […]

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.

Anand, A et al. (2023).  Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.  N Engl J Med 2023;388:2315-25. DOI: 10.1056/NEJMoa2302399  Highlights: A total of 55.4% of the patients in the ketamine group and 41.2% of those in the ECT group had a response. Patients with treatment-resistant major depression without psychosis were recruited and assigned in […]

Ketamine normalizes subgenual cingulate cortex hyper-activity in depression.

Morris, L. S., Costi, S., Tan, A., Stern, E. R., Charney, D. S., & Murrough, J. W. (2020). Ketamine normalizes subgenual cingulate cortex hyper-activity in depression. Neuropsychopharmacology, 45(6), 975–981.  Highlights: There was a significant improvement in MDD symptoms following a single-dose intravenous ketamine. Following a 40-minute infusion of ketamine at a dose of 0.5mg/kg, patients […]

Ketamine for Treatment-Resistant Mood Disorders

ketamine Nasal spray bottle

Highlights: Strong evidence supports the rapid, although temporary, antidepressant effects of a single intravenous ketamine infusion for treatment-resistant major depressive disorder (MDD) and bipolar depression. Intravenous ketamine administration for treatment-resistant depression (TRD) is generally safe and well tolerated when administered by trained professionals. Ketamine research is transforming our understanding of the pathophysiology of mood disorders […]

Ketamine for Treatment-Resistant Mood Disorders.

Park LT, Falodun TB, Zarate CA Jr. Ketamine for Treatment-Resistant Mood Disorders. Focus (Am Psychiatr Publ). 2019 Jan;17(1):8-12. doi: 10.1176/appi.focus.20180030. Epub 2019 Jan 7. PMID: 31975953; PMCID: PMC6493154.   Highlights: Strong evidence supports the rapid, although temporary, antidepressant effects of a single intravenous ketamine infusion for treatment-resistant major depressive disorder (MDD) and bipolar depression. Intravenous […]

Increased reactivity of the mesolimbic reward system after ketamine injection in patients with treatment-resistant major depressive disorder.

Sterpenich, V., Vidal, S., Hofmeister, J., Michalopoulos, G., Bancila, V., Warrot, D., Dayer, A., Desseilles, M., Aubry, J.-M., Kosel, M., Schwartz, S., & Vutskits, L. (2019). Increased reactivity of the mesolimbic reward system after ketamine injection in patients with treatment-resistant major depressive disorder. Anesthesiology, 130(6), 923–935.   Highlights: As expected, ketamine administration led to an […]

Improvement in suicidal ideation after repeated ketamine infusions.

Albott, C. S., Lim, K. O., Forbes, M. K., Thuras, P., Wels, J., Tye, S., & Shiroma, P. (2019). 3525 Improvement in suicidal ideation after repeated ketamine infusions: Journal of Clinical and Translational Science, 3(s1), 46–46.   Highlights: This study showed significant improvement in suicidal ideation within 24 hours of the first ketamine infusion therapy […]

Ketamine as a Novel Treatment for Major Depressive Disorder and Bipolar Depression: A Systematic Review and Quantitative Meta-Analysis.

Lee EE, Della Selva MP, Liu A, Himelhoch S. Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis. Gen Hosp Psychiatry. 2015 Mar-Apr;37(2):178-84. doi: 10.1016/j.genhosppsych.2015.01.003. Epub 2015 Jan 15. PMID: 25698228. Highlights: Quantitative meta-analysis of six randomized placebo-controlled trials conducted in September 2013 of ketamine treatment […]

Do the dissociative side effects of ketamine mediate its antidepressant effects?

Luckenbaugh DA, Niciu MJ, Ionescu DF, Nolan NM, Richards EM, Brutsche NE, Guevara S, Zarate CA. Do the dissociative side effects of ketamine mediate its antidepressant effects? J Affect Disord. 2014 Apr;159:56-61. doi: 10.1016/j.jad.2014.02.017. Epub 2014 Feb 18. PMID: 24679390; PMCID: PMC4065787. Highlights: Dissociative effects predicted a better and longer antidepressant effect. 108 treatment-resistant inpatient […]

Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder.

  Ghasemi M, Kazemi MH, Yoosefi A, Ghasemi A, Paragomi P, Amini H, Afzali MH. Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder. Psychiatry Res. 2014 Feb 28;215(2):355-61. doi: 10.1016/j.psychres.2013.12.008. Epub 2013 Dec 13. PMID: 24374115. Highlights: In this blind, randomized study, 18 patients […]