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Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

R.N. Moda-Sava, M.H. Murdock, P.K. Parekh, R.N. Fetcho, B.S. Huang, T.N. Huynh, J. Witztum, D.C. Shaver, D.L. Rosenthal, E.J. Alway, K. Lopoz, Y. Meng, L. Nellissen, L. Grosenick, T.A. Milner, K.Deisseroth, H. Bito, H. Kasai, C. Liston.  Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.  2019 Apr 12; Vol 364, Issue 6436. DOI: […]

(R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress. Ketamine demonstrates neuroplasticity. Neuroplasticity is hypothesized to be a key component to mental health recovery.

Zhang J, Qu Y, Chang L, Pu Y, Hashimoto K. (R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress. Int J Neuropsychopharmacol. 2019 Oct 1;22(10):675-679. doi: 10.1093/ijnp/pyz048. PMID: 31504547; PMCID: PMC6822137. Highlights: This study suggests that (R)-ketamine rapidly ameliorates the decreased spine […]

Ketamine triggers a switch in excitatory neuronal activity across neocortex.

Cichon, J., Wasilczuk, A.Z., Looger, L.L. et al. Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nat Neurosci (2022). Highlights: Ketamine reorganizes neuronal activity and switches on active circuits. In mice, this study demonstrates that ketamine causes spontaneously active neurons to become deactivated and reactivates prior spontaneously deactivated neurons. This switch occurs in […]

Ketamine normalizes subgenual cingulate cortex hyper-activity in depression.

Morris, L. S., Costi, S., Tan, A., Stern, E. R., Charney, D. S., & Murrough, J. W. (2020). Ketamine normalizes subgenual cingulate cortex hyper-activity in depression. Neuropsychopharmacology, 45(6), 975–981.  Highlights: There was a significant improvement in MDD symptoms following a single-dose intravenous ketamine. Following a 40-minute infusion of ketamine at a dose of 0.5mg/kg, patients […]

Do the dissociative side effects of ketamine mediate its antidepressant effects?

Luckenbaugh DA, Niciu MJ, Ionescu DF, Nolan NM, Richards EM, Brutsche NE, Guevara S, Zarate CA. Do the dissociative side effects of ketamine mediate its antidepressant effects? J Affect Disord. 2014 Apr;159:56-61. doi: 10.1016/j.jad.2014.02.017. Epub 2014 Feb 18. PMID: 24679390; PMCID: PMC4065787. Highlights: Dissociative effects predicted a better and longer antidepressant effect. 108 treatment-resistant inpatient […]