Clinical trials
One Dose After Delivery: A Trial of Esketamine to Prevent Postpartum Depression
A 2024 trial in The BMJ gave new mothers with prenatal depressive symptoms a single low dose of esketamine after childbirth. Major depression at six weeks fell from about 25% to under 7%.
Ketamine or ECT? A Follow-Up Study Shows Who Benefits From Which
A 2024 follow-up to the ELEKT-D trial looked at 365 patients to see who did better with ketamine and who did better with ECT. Severity and setting made the difference.
When Ketamine Did Not Beat the Comparison: Lessons From the KARMA-Dep 2 Trial
A 2025 trial in JAMA Psychiatry found that adding ketamine infusions to inpatient depression care worked no better than an active comparison drug. What it means, and what it does not.
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