| Method |
 Intravenous Infusion (IV)
|
 Intramuscular Injection (IM)
|
 Intranasal Spray
|
 Sublingual Rapid Dissolve Tablet
|
|
Route
|
 Direct administration into a vein
|
 Injection into the muscle
|
 Administration by inhaling a spray into the nostrils
|
 Under the tongue absorption through the membranes of the mouth
|
|
Treatment Program
|
 6 times in 2-4 weeks
|
 8 times in 4-6 weeks
|
8 times in 4-6 weeks
|
 Daily or intermittent use over multiple months
|
|
Dosage
|
 Individually tailored sub-anesthetic amount enough to induce dissociative effect
|
Individually tailored sub-anesthetic amount enough to induce dissociative effect
|
Individually tailored sub-anesthetic amount enough to induce dissociative effect
|
 Individually tailored lower than macro-dosing standard, typically not to induce dissociative effect
|
|
Bioavailability
|
100% |
93% |
40-50% |
25-40% |
|
Onset of Action
|
 1 min
|
 5 mins
|
 15 mins
|
 10-20 mins
|
|
Strategy
|
 Fully controllable titration of dosing to achieve optimal therapeutic effect in the least number of sessions
|
 Uncontrollable dosing to achieve intense therapeutic effect in a few numbers of session
|
 Controllable dosing to achieve good therapeutic effect in a few numbers of sessions
|
 Collaborative managed low dosage treatment designed for long-term maintenance in sustaining ketamine’s therapeutic effect
|
|
Effects & Experience
|
 May induce profound psychedelic effect of dissociation or “out of body experience
|
May induce profound but short psychedelic effect of dissociation or “out of body experience”
|
May induce psychedelic effect of dissociation or “out of body experience”
|
Typically, no trigger significant dissociative effect, but still provide antidepressant and antianxiety experience
|
|
Monitoring
|
 Under the supervision of a medical provider each session
|
Under the supervision of a medical provider each session
|
Under the supervision of a medical provider each session
|
 Self-administer under the direction of a medical provider
|
|
Integration Therapy
|
 Recommended |
Recommended |
Recommended |
 Optional |
|
Price
|
 $3000 for 6 dosing sessions |
$3600 for 8 dosing sessions |
$3600 for 8 dosing sessions |
 Starting at $129 per month* |
|
Booster (as needed)
|
 $499 per session |
$449 per session |
 $429 per session |
No booster necessary |
|
Appointment
|
 Schedule |
Schedule |
Schedule |
Schedule |
