A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression.
Singh JB, Fedgchin M, Daly EJ, De Boer P, Cooper K, Lim P, Pinter C, Murrough JW, Sanacora G, Shelton RC, Kurian B, Winokur A, Fava M, Manji H, Drevets WC, Van Nueten L. A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression. Am J Psychiatry. 2016 Aug 1;173(8):816-26. doi: […]
Ketamine as a Novel Treatment for Major Depressive Disorder and Bipolar Depression: A Systematic Review and Quantitative Meta-Analysis.
Lee EE, Della Selva MP, Liu A, Himelhoch S. Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis. Gen Hosp Psychiatry. 2015 Mar-Apr;37(2):178-84. doi: 10.1016/j.genhosppsych.2015.01.003. Epub 2015 Jan 15. PMID: 25698228. Highlights: Quantitative meta-analysis of six randomized placebo-controlled trials conducted in September 2013 of ketamine treatment […]
Do the dissociative side effects of ketamine mediate its antidepressant effects?
Luckenbaugh DA, Niciu MJ, Ionescu DF, Nolan NM, Richards EM, Brutsche NE, Guevara S, Zarate CA. Do the dissociative side effects of ketamine mediate its antidepressant effects? J Affect Disord. 2014 Apr;159:56-61. doi: 10.1016/j.jad.2014.02.017. Epub 2014 Feb 18. PMID: 24679390; PMCID: PMC4065787. Highlights: Dissociative effects predicted a better and longer antidepressant effect. 108 treatment-resistant inpatient […]
Ketamine Infusion for Obsessive-Compulsive Disorder.
Bloch MH. Ketamine Infusion for Obsessive-Compulsive Disorder. ClinicalTrials.gov. 2014 June; https://clinicaltrials.gov/study/NCT01349231 Highlights: In a placebo-controlled study completed at Yale, a single dose of ketamine (0.5 mg/kg, intravenously) had rapid antidepressant effects in depressed patients. In these subjects, ketamine infusion produced mild psychotomimetic symptoms and euphoria that dissipated within 120 minutes, while the antidepressant effects of […]
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder.
Feder, A., Parides, M. K., Murrough, J. W., Perez, A. M., Morgan, J. E., Saxena, S., Kirkwood, K., aan het Rot, M., Lapidus, K. A., Wan, L.-B., Iosifescu, D., & Charney, D. S. (2014). Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder. JAMA Psychiatry, 71(6), 681–688 Highlights: Objective: To test the efficacy […]
Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder.
Ghasemi M, Kazemi MH, Yoosefi A, Ghasemi A, Paragomi P, Amini H, Afzali MH. Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder. Psychiatry Res. 2014 Feb 28;215(2):355-61. doi: 10.1016/j.psychres.2013.12.008. Epub 2013 Dec 13. PMID: 24374115. Highlights: In this blind, randomized study, 18 patients […]
Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression.
Shiroma, Johns et al. Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment-resistant depression” Journal of Affective Disorders. 2014 Feb;155:123-9. Highlights: In this study, we determined antidepressant response and remission to six consecutive ketamine infusions while maintaining stable doses of the antidepressant regimen. We also examined the trajectory of response and remission […]
Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept.
Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., Flood, P., & Simpson, H. B. (2013). Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept. Neuropsychopharmacology, 38(12), 2475–2483. Highlights: Participants receiving ketamine first showed a significant rapid reduction in obsessions during the infusion that persisted until 1 week […]
Transient resolution of treatment-resistant posttraumatic stress disorder following ketamine infusion.
D’Andrea, D., & Sewesll, R. A. (2013). Transient resolution of treatment-resistant posttraumatic stress disorder following ketamine infusion. Biological Psychiatry, 74(9), e13–e14. Highlights: An N-methyl-D-aspartate (NMDA) receptor antagonist with μ-opioid receptor effects, ketamine causes depression remission in most clinical trials attracting interest as a rapid-acting antidepressant We describe a case in which ketamine was given for treatment-resistant […]
Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.
Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CE, Perez AM, Iqbal S, Pillemer S, Foulkes A, Shah A, Charney DS, Mathew SJ. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013 Oct;170(10):1134-42. doi: 10.1176/appi.ajp.2013.13030392. PMID: 23982301; PMCID: PMC3992936. Highlights: Ketamine showed rapid antidepressant effects […]
