Ketamine works differently from traditional medications used to treat Post-Traumatic Stress Disorder (PTSD). Instead of targeting serotonin or dopamine, ketamine acts on the glutamate system in the brain—specifically the NMDA receptors—which play a key role in memory, learning, and emotional processing.

By modulating these pathways, ketamine helps to:

• Reduce the intensity and frequency of intrusive thoughts and flashbacks

• Interrupt traumatic memory loops

• Enhance emotional resilience and flexibility

• Support neuroplasticity (the brain’s ability to form new, healthier connections)

Many patients report rapid relief from symptoms—often within hours or days—especially when ketamine is delivered through IV, IM, or intranasal routes. It may also help patients become more receptive to trauma-focused therapy, such as EMDR or prolonged exposure therapy.

At AVYIA, ketamine treatment for PTSD is personalized and closely monitored, and we often recommend combining it with therapy or counseling to maximize long-term benefits.

Each ketamine treatment experience is unique, especially for individuals living with Post-Traumatic Stress Disorder (PTSD). Your responses may vary from session to session, and that’s completely normal.

At the therapeutic doses used for IV, IM, and intranasal administration, many patients experience dissociative or psychedelic effects—a temporary state that may feel like an out-of-body experience or entering a dreamlike space. Some describe this as “going on a trip.” Feelings of euphoria, emotional release, or a surreal shift in perception are also common.

For those with PTSD, ketamine can sometimes bring up intense emotions or memories, but many patients also experience a sense of emotional catharsis—a safe release of trauma that may have been difficult to access through traditional therapy alone. This can be followed by introspection, clarity, or a deeper connection to one’s thoughts and emotions.

While these experiences can feel profound or symbolic—such as having a “false epiphany” or gaining sudden meaning—they are typically short-lived. Most patients return to their baseline mental state within a few hours, and nearly all by the next day.

To ensure your safety and comfort:

• Avoid driving or making major decisions for the rest of the day.

• A responsible adult should be present to accompany you after each treatment.

• Our team will monitor you closely during and after the session, providing a safe and supportive environment.

Ketamine can be a powerful tool in PTSD recovery, especially when combined with therapy and trauma-informed care. At AVYIA, we’re here to support you every step of the way.

Yes. While ketamine has gained attention for its effectiveness in treating Post-Traumatic Stress Disorder (PTSD), it has also shown significant promise in treating a range of other mental health and neurological conditions, especially when other treatments have failed.

Here are some of the most common conditions ketamine is used to treat:

• Depression (including treatment-resistant depression)

• Anxiety disorders

• Obsessive-Compulsive Disorder (OCD)

• Bipolar depression (not during manic or hypomanic episodes)

• Suicidal ideation

• Chronic pain syndromes (e.g., fibromyalgia, CRPS)

• Migraines

• Substance use disorders (in conjunction with behavioral therapy)

Ketamine works differently from traditional medications. By targeting the glutamate system and promoting neuroplasticity, ketamine helps the brain “reset” unhealthy patterns of thought and emotion—making it a valuable option for people who haven’t found relief with conventional treatments.

At AVYIA, we offer personalized ketamine protocols tailored to your diagnosis, treatment history, and goals, using multiple routes of administration—IV, IM, intranasal, and oral microdosing.

Ketamine can provide rapid relief for many individuals with Post-Traumatic Stress Disorder (PTSD)—often much faster than traditional medications.

Many patients report noticeable improvements in mood, anxiety, and intrusive thoughts within hours to a few daysafter their first IV, IM, or intranasal treatment. These improvements may include:

• Reduced emotional reactivity to trauma triggers

• Fewer flashbacks or nightmares

• Increased sense of calm and emotional stability

That said, not everyone responds immediately. Some patients may require several sessions to experience full benefits, especially if PTSD symptoms are severe or longstanding.

Oral microdosing tends to have a slower onset, with subtle effects building over days to weeks. However, many still report early emotional relief and improved sleep within the first few days.

At AVYIA, we tailor your treatment plan to your unique needs, and we monitor your response closely to ensure you’re supported every step of the way.

Ketamine is not typically included in standard drug panels, such as those used for employment or routine screenings. However, if a drug test is specifically designed to detect ketamine, it can and will show up.

At AVYIA, ketamine therapy is strictly medical and therapeutic—not recreational. We encourage patients to inform and involve trusted family members or support systems throughout their treatment journey for additional safety and emotional support.