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Can exposure-based CBT extend the effects of intravenous ketamine in obsessive-compulsive disorder? an open-label trial. J Clin Psychiatry.

Rodriguez CI, Wheaton M, Zwerling J, Steinman SA, Sonnenfeld D, Galfalvy H, Simpson HB. Can exposure-based CBT extend the effects of intravenous ketamine in obsessive-compulsive disorder? an open-label trial. J Clin Psychiatry. 2016 Mar;77(3):408-9. doi: 10.4088/JCP.15l10138. PMID: 27046314; PMCID: PMC5544939. Highlights: IV ketamine can rapidly reduce obsessions in unmedicated OCD patients and advance the growing […]

Ketamine Infusion for Obsessive-Compulsive Disorder.

Bloch MH.  Ketamine Infusion for Obsessive-Compulsive Disorder. ClinicalTrials.gov.  2014 June; https://clinicaltrials.gov/study/NCT01349231 Highlights: In a placebo-controlled study completed at Yale, a single dose of ketamine (0.5 mg/kg, intravenously) had rapid antidepressant effects in depressed patients. In these subjects, ketamine infusion produced mild psychotomimetic symptoms and euphoria that dissipated within 120 minutes, while the antidepressant effects of […]

Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept.

Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., Flood, P., & Simpson, H. B. (2013). Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept. Neuropsychopharmacology, 38(12), 2475–2483. Highlights: Participants receiving ketamine first showed a significant rapid reduction in obsessions during the infusion that persisted until 1 week […]