Sarah Brand

Sarah Brand

Ketamine’s dose-related effects on anxiety symptoms in patients with treatment refractory anxiety disorders.

Glue P, Medlicott NJ, Harland S, Neehoff S, Anderson-Fahey B, Le Nedelec M, Gray A, McNaughton N. Ketamine’s dose-related effects on anxiety symptoms in patients with treatment-refractory anxiety disorders. J Psychopharmacol. 2017 Oct;31(10):1302-1305. doi: 10.1177/0269881117705089. Epub 2017 Apr 26. PMID: 28441895.


  • Within 1 h of dosing, patients reported reduced anxiety, which persisted for up to seven days.
  • Due to similarities in brain network activity in depression and anxiety disorders, we hypothesized that ketamine might also be active in other refractory anxiety disorders. We evaluated the efficacy and safety of ketamine in 12 patients with refractory generalized anxiety disorder and/or social anxiety disorder who were not currently depressed, using an ascending single-dose study design (0.25, 0.5, 1 mg/kg administered subcutaneously) at weekly intervals.


  • Ketamine was safe and well tolerated in this population. Ketamine may be a potential therapeutic alternative for patients with refractory generalized anxiety disorder/social anxiety disorder.
  • Along with its demonstrated effectiveness in patients with treatment-resistant depression, obsessive-compulsive disorder, and post-traumatic stress disorder, these data raise the intriguing possibility that ketamine may have broad efficacy in disorders characterized by negative emotional states and that these disorders may share a common precipitating neurobiology.

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